Ascend - Obesity Study Sponsor and Protocol Number: AstraZeneca D8460C00004 Specialty: Internal Medicine Type: Investigational Drug Inclusion: Age 18 - 75 BMI > 27 Highly effective birth control Exclusion: Use of any weight loss medication in the last 3 months Use of THC-containing products DiabetesHistory of severe mental health disordersRemoval of gallbladder